The bottom two in the Premier Division lock horns as rock-bottom Mulgrave host Ebberston on Saturday in what could prove a critical fixture.
Elsewhere, title favourites and champs Staithes are at Nawton Grange for a potentially tricky tie, while their main rivals Staxton play host to Seamer.
In Division One, Brompton are at home to Staxton 2nds, while leaders Settrington make the journey to Wykeham looking to boost their promotion push.
Division Two leaders Bridlington 2nds ought to win at home to Scarborough 3rds, while Division Three's top two Seamer 2nds and Kirkbymoorside are at home to Ryedale and Flixton 3rds respectively.
Division Four runaway leaders Snainton host in-form Cloughton 2nds, while two of the promotion chasers in Division Five lock horns as Forge Valley 3rds welcome Valley Bar Nomads.
SATURDAY
Premier Division (1:30pm)
Filey v Forge Valley
Mulgrave v Ebberston
Scalby v Heslerton
Nawton Grange v Staithes
Staxton v Seamer
Division 1 (1:30pm)
Brompton v Staxton 2nds
Cayton 2nds v Thornton Dale
Cloughton v Wold Newton
Sherburn v Grindale
Wykeham v Settrington
Division 2 (1:30pm)
Bridlington 2nds v Scarborough 3rds
Forge Valley 2nds v Sewerby 2nds
Ganton v Fylingdales
Ebberston 2nds v Great Habton
Ravenscar v Scalby 2nds
Division 3 (1:30pm)
Flamborough v Nawton Grange 2nds
Heslerton 2nds v Muston
Kirkbymoorside v Flixton 3rds
Seamer 2nds v Ryedale
Wykeham 2nds - No game
Division 4 (2pm)
Hospitals Rugby Club v Sherburn 2nds
Lockton v Filey 2nds
Snainton v Cloughton 2nds
Wold Newton 2nds v Cayton 3rds
Division 5 (2pm)
Forge Valley 3rds v Valley Bar Nomads
Muston 2nds v Ganton 2nds
Scalby 3rds v Ravenscar 2nds
Thornton Dale 2nds v Wykeham 3rds